How to avoid and improve the treatment of lung complications derived from allergic reactions

Agostinho Albérico Rodrigues de Carvalho

Project awarded in collaboration with the Fundação para a Ciência e a Tecnologia

  • PROJECT LEADER

    Agostinho Albérico Rodrigues de Carvalho

  • HOST ORGANIZATION,
    COUNTRY

    Universidade do Minho (UM), Portugal

  • DESCRIPTION

    People with chronic obstructive pulmonary disease (COPD) are at high risk of developing chronic pulmonary aspergillosis, an allergic reaction to the fungus aspergillus, which is found in the air we breathe. Healthy people are not affected, but the population with previous pathologies is at risk.

    In Spain, 4,000 new cases of chronic pulmonar aspergillosis, a disease with devastating consequences for the lungs, are diagnosed each year. The reduction in quality of life and mortality is very high.

    The project investigates, through genetic sequencing techniques, the pathogenic mechanisms of the disease and the change in the response of the immune system to this infection.

    The aim is to identify new biomarkers that indicate susceptibility to this infection in patients with previous lung diseases to improve prevention and diagnosis, and the design of personalized therapies.

  • CONSORTIUM
    (PRINCIPAL INVESTIGATOR,
    ORGANIZATION, COUNTRY)

    • Coral Barbas Arribas (Co-Líder), Fundación Universitaria San Pablo (CEU), Spain

    • Georgios Chamilos, University of Crete, Greece

    • Alexander Mosig, Jena University Hospital, Germany

    • Frank L. van de Veerdonk, Stichting Katholieke Universiteit (SKU), Holland

  • PROJECT TITLE

    A Transdisciplinary Approach to the Identification of Personalized Biomarkers and Therapeutic Targets for Chronic Pulmonary Aspergillosis

  • BUDGET

    €999,027