Better understanding of the mutations present in T-lymphocyte lymphomas to improve their diagnosis and treatment

Xosé R. Bustelo


    Xosé R. Bustelo


    Centro de Investigación del Cáncer de Salamanca, Spain


    Cancer is characterised by presenting a huge number of genetic alterations. However, we currently know the role of only a few of them in the development and malignant progression of the disease.

    T-lymphocytes are a type of immune system cell responsible for recognising and destroying cells in our organism that have become cancerous or infected by a virus. They also enhance the responses of other immune system cells such as B lymphocytes. However, in some cases T-lymphocytes suffer genetic alterations that makes them cancerous. The tumours derived from these cells, known as lymphomas, are characterised by a low short-term survival rate of patients and by the absence of effective treatments.

    This research project will focus on the study of a series of genetic alterations in the RHOA gene which are very frequently found in T-lymphocyte-derived lymphomas.

    In addition to contributing to a better understanding of how this tumour type originates, the study is expected to reveal hitherto unknown information which will enable better stratification and treatment of patients affected by this type of cancer.


    A new functional paradigm for RHOA gene mutations in peripheral T cell lymphoma: functional and clinical implications (UNCHARTED RHOADS)


    498.300 €