Fluorescent sensors to study the physical forces in tumours
HOST ORGANIZATION, COUNTRY
Institut de Bioenginyeria de Catalunya, Spain
A malign tumour is characterised by its capacity to spread. Cancerous cells adhere to the tissue that surrounds them and exercise mechanical forces to grow, invade organs and tissues, and disseminate throughout the organism.
Until now, advances in this field have been hampered by the lack of technologies that enable visualisation of these physical forces in the cell nucleus, key in the gene expression process and progression of the disease.
The project will develop fluorescent sensors to visualise physical forces in the interior of the cell nucleus during tumour invasion and metastasis. This will lead to new possibilities of diagnosis and treatment.
(PRINCIPAL INVESTIGATOR, ORGANIZATION, COUNTRY)
Jacco van Rheenen, Netherlands Cancer Institute, Países Bajos
Enabling technologies to map nuclear mechanosensing: from organoids to tumors (Mech4Cancer)