New targets to slow the progression of bladder and pancreatic cancer
Centre de Regulació Genòmica (CRG), Spain
The RBM10 gene codes for a protein that affects the regulation of the genetic material in processes related to development, heart function and inflammation. Some tumours have alterations in this gene.
Specifically, RBM10 has mutations in 10% of lung cancers, 5%-8% of bladder cancers and 5% of pancreatic cancers. Together, these amount to 1.5 million new cases a year worldwide.
After analysing the role of this gene in lung cancer, the project is now investigating the consequences of inactivating RBM10 in bladder and pancreatic cancer tumours with a view to identifying new therapeutic targets and slowing their progression.
Centro Nacional de Investigaciones Oncológicas (CNIO), Spain
RBM10, a novel splicing regulator and tumor suppressor: from mechanisms to therapies