Drug resistance and metastasis, keys to improve cancer survival
i3S - Instituto de Investigação e Inovação em Saúde, Portugal
The cells of the human body divide 10,000 trillion times throughout life. Tubulins are a family of proteins that assemble into microtubules, which are essential for correct cell division.
For this reason, many of the current therapeutic drugs to fight cancer interfere with cell division, migration and invasion by targeting microtubules.
The project investigates the impact of tubulin and microtubule diversity on resistance to cancer drugs and cancer metastases, two of the greatest challenges to improve patient survival.
Cracking the cancer tubulin code for precision oncology