Results of the Health Research 2020 Grant Applications

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  • DATA 2020

    The Health Research 2020 Programme has awarded a total of 18 million euros to 25 biomedical research projects. Of the finalist projects, 21 have been selected by the HR20 Call, 3 have been chosen in collaboration with the Fundação para a Ciência e a Tecnologia (FCT) of the Ministry of Science, Technology and Higher Education of Portugal, and 1 in collaboration with the Luzón Foundation.

    Information concerning the HR20 grant application process and the results are presented below: number of projects submitted, pre-selected and selected by thematic area and category, as well as the territorial distribution of the budget for the selected projects.

    HEALTH RESEARCH 2020 CALL FOR PROPOSALS - INFORMATION

    HR20 Budget

    15.200.128 €

    Number of projects presented

    602

    Number of projects evaluated

    600

    Number of projects preselected

    62

    Number of projects selected

    21

    Success rate

    3,50%

    Table 1: General information of Health Research 2020 Call for Proposals.

    Figure 1: Budget distribution by territory

    Figure 1: Budget distribution by territory

    THEMATIC AREA PROJ. EVALUATED PROJ. PRESELECTED (PEER REVIEW) PROJ. SELECTED (EXPERT PANEL)

    Cardiovascular and metabolic diseases

    75

    12

    16,00%

    4

    5,33%

    Neuroscience

    163

    14

    8,59%

    5

    3,07%

    Infectious diseases

    82

    12

    14,63%

    4

    4,88%

    Oncology

    139

    12

    8,63%

    4

    2,88%

    Enabling technologies

    141

    12

    8,51%

    4

    2,84%

      600 62 10,33% 21 3,50%

    Table 2: % of the preselected and selected projects compared to the presented projects in each thematic area.

    THEMATIC AREA PROJ. EVALUATED PROJ. PRESELECTED PROJ. SELECTED

    Cardiovascular and metabolic diseases

    Individual

    22

    2

    1

    Research Consortium

    53

    10

    3

    Total

    75

    12

    4

    Neuroscience

    Individual

    76

    5

    4

    Research Consortium

    87

    9

    1

    Total

    163

    14

    5

    Infectious disease

    Individual

    31

    4

    1

    Research Consortium

    51

    8

    3

    Total

    82

    12

    4

    Oncology

    Individual

    68

    3

    2

    Research Consortium

    71

    9

    2

    Total

    139

    12

    4

    Enabling technologies

    Individual

    44

    3

    1

    Research Consortium

    97

    9

    3

    Total

    141

    12

    4

     

     

    600 62 21

    Table 3: Number of Individual and Research Consortium projects compared to the total number of projects of each thematic area.

Evaluation process

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  • REMOTE EVALUATION PHASE

    • The proposals were evaluated by a total of 245 experts: at least three per project

    • Proposals were assigned through a process of matching between assessors and projects, taking into account the thematic area, disciplines and keywords.

    • The final score for each project has been adjusted based on two standardization coefficients related to the strictness of each evaluator and the level of coincidence in the matching process.

    • There were 10 proposals with a discrepancy of more than 2.5 points and with the possibility of passing to the interview phase, which were evaluated by a fourth evaluator. The mean score was calculated taking into account the four standardized scores.

  • INTERVIEW PHASE

    The top 12-14 proposals per thematic area according to the ranking established according to the remote evaluation scores proceeded to this phase.

    The interviews were evaluated by panels made up of six to eight experts selected for their excellence and area of expertise, seeking a balance between basic, clinical and translational profiles.

    The process adopted was as follows:

    • Face-to-face interviews where the project will be presented followed by questions.

    • Discussion and assignment of grades by the members of the panel.

    • Individual review of grades by each evaluator and presentation of the initial ranking of projects.

    • Discussion, deliberation and, if necessary, adjustment of the grades by members of the panel.

    • Presentation of the final ranking.

  • LIST

Summary of selected projects

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See each selected project, here

CODE PROJECT TITLE PROJECT LEADER HOST INSTITUTION PARTNER INSTITUTIONS THEMATIC AREA CATEGORY BUDGET (€)

HR20-00493

Function of a novel program of islet microexons in beta cell development, insulin secretion and diabetes

Manuel Irimia

Centre de Regulació Genòmica (CRG)

N/A

Cardiovascular and metabolic diseases

Individual

499.592

HR20-00075

Flow-driven inflammation and arterial wall remodeling in atherosclerosis: mechanisms and therapeutic potential

Miguel Ángel Del Pozo

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC

Yale University, New Haven, CT, Aarhus University, Asociación Centro de Investigación Cooperativa en Biomateriales

Cardiovascular and metabolic diseases

Research Consortium

999.987

HR20-00322

RNA mis-splicing in hypertrophic cardiomyopathy: opportunities for diagnosis and therapy

Maria Carmo-Fonseca

Instituto de Medicina Molecular

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Associação para Investigação e Desenvolvimento da Faculdade de Medicina

Cardiovascular and metabolic diseases

Research Consortium

986.964

HR20-00051

Succinate/SUCNR1 axis: a novel target for anti-obesity therapies

Sonia Fernandez

Fundació Institut d'Investigació Sanitària Pere Virgili

Universidad de Santiago de Compostela, Institut D'Investigació Biomèdica De Girona (IDIBGI)

Cardiovascular and metabolic diseases

Research Consortium

998.902

HR20-00369

Enabling technologies to map nuclear mechanosensing: from organoids to tumors

Xavier Trepat

Institut de Bioenginyeria de Catalunya

Netherlands Cancer Institute

Enabling technologies

Research Consortium

984.630

HR20-00800

Deep Learning to Dissect the Interaction between Leukemic Cells and the Ageing Niche

M. Carolina Florian

Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)

Universität Ulm

Enabling technologies

Research Consortium

817.045

HR20-00637

BioPrinted hydROgel MicrofluIdicS to mimic patient-specific tumor mEtastatic microenvironment

Elena Martinez

Institut de Bioenginyeria de Catalunya

Laboratorio Ibérico Internacional de Nanotecnologia, Fundació privada Institut Investigació Oncologica Vall Hebron (VHIO)

Enabling technologies

Research Consortium

981.675

HR20-00428

Heterogenous protein acylation and cancer

Gemma Triola

Consejo Superior de Investigaciones Científicas (CSIC)

N/A

Enabling technologies

Individual

341.242

HR20-00218

Enhancing Tissue-Specific Immune Microenvironments for the Cure of HIV

María José Buzón

Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR)

Consejo Superior de Investigaciones Científicas (CSIC), Institut de Recerca de la Sida "la Caixa" - IRSICAIXA

Infectious diseases

Research Consortium

699.134

HR20-00361

Mechanism and function of epitranscriptomic poly(A) tail modifications in African trypanosomes

Luisa Figueiredo

Instituto de Medicina Molecular Joao Lobo Antunes

N/A

Infectious diseases

Individual

499.400

HR20-00635

Coping with unpredictability: regulatory plasticity as an adaptation strategy in the human malaria parasite

Elena Gomez

Consejo Superior de Investigaciones Científicas (CSIC)

University of Glasgow, University of Sciences, Techniques and Technologies of Bamako (USTTB), Malaria Rsearch and Training Center

Infectious diseases

Research Consortium

999.548

HR20-00584

Discovery of new antiparasitic drug candidates and innovative modes of actions from Microbial Natural Products

Olga Genilloud

Fund. Centro de Excelencia en Inv. de Medicamentos Innovadores en Andalucia

Drugs for Neglected Diseases Initiative (DNDi), Institut Pasteur korea

Infectious diseases

Research Consortium

995.251

HR20-01000

Encoding reward and aversion in the mammalian brain: the overlooked role of endogenous opioids

Ana Joao Rodrigues

Universidade do Minho

N/A

Neuroscience

Individual

499.788

HR20-00083

Restoration of sensory circuits based on glia-to-neuron reprogramming

Guillermina López-Bendito

Consejo Superior de Investigaciones Científicas (CSIC)

N/A

Neuroscience

Individual

499.000

HR20-00081

Amino acid transporter structure to target glutamate transmission in neuro diseases

Manuel Palacin

Fundació Institut de Recerca Biomèdica (IRB Barcelona)

Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III

Neuroscience

Research Consortium

428.500

HR20-00896

Mitochondrial transcription as a trigger for neurodegenation

Albert Quintana

Universitat Autònoma de Barcelona (UAB)

N/A

Neuroscience

Individual

500.000

HR20-00714

A cortical pathogenesis of Parkinson's disease

Guglielmo Foffani

Fundación de Investigación HM Hospitales

N/A

Neuroscience

Individual

500.000

HR20-00465

Immunomodulatory drivers in melanoma progression and therapy response

Maria Soengas

Fund. del Sector Público Estatal Centro Nacional de Inv. Oncológicas Carlos III

N/A

Oncology

Individual

481.597

HR20-00164

A new functional paradigm for RhoA gene mutations in peripherial Tcell Lymphoma: Functional and Clinical implications

Xose R. Bustelo

Fundación de Investigación del Cancer

N/A

Oncology

Individual

498.300

HR20-00871

Gene Regulatory NETworks in NORmal and MALignant Hematopoiesis-Identification and Targeting (GR-NET NORMAL-HIT)

Felipe Prosper

Universidad de Navarra

Fundación para la Investigación Médica Aplicada (FIMA/CIMA), Fundación Miguel Servet - Navarrabiomed, University of Cambridge

Oncology

Research Consortium

999.410

HR20-00411

Virtual patient derived xenografts for tumor treatment

Luciano Di Croce

Centre de Regulació Genòmica (CRG)

Fundació Sant Joan de Déu

Oncology

Research Consortium

990.160

Projects awarded in collaboration with the Fundación Luzón

HR20-01109

Brain Liquid Biopsy for Alzheimer disease and neurodegenerative disorders

Maite Mendioroz

Fundación Miguel Servet - Navarrabiomed

N/A

Neuroscience

Individual

482.847

Projects awarded in collaboration with the Fundação para a Ciência e a Tecnologia, I.P. within the “Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b"

HR20-00249

Diamond Photonics Platforms for Synaptic Connectivity Assessment in Healthy and Parkinson Disease Neuronal Models

Jana B. Nieder

Laboratorio Ibérico Internacional de Nanotecnologia

Universidade do Minho, Universidade de Aveiro

Enabling technologies

Research Consortium

999.981

HR20-00841

Unravelling pulmonary neuroimmune circuits during infection

Henrique Veiga-Fernandes

Fundação D. Anna Sommer Champalimaud e Dr. Carlos Montez Champalimaud

N/A

Infectious disease

Individual

499.950

HR20-00904

Potassium channel dysfunction in models of neurodevelopmental disorders

Ana Luisa Carvalho

Centro de Neurociências e Biologia Celular

IINS - Interdisciplinary Institute for Neuroscience, CNRS 5297, University of Bordeaux

Neuroscience

Research Consortium

782.000